We are focused on the complex molecular and cellular mechanisms that control the host inflammatory response, especially the signaling events that lead to changes in cellular structure and function.
Receptors on the cell surface sense and respond to extracellular ligands and transmit the signals to the cell interior. We are particularly interested in the signal transduction pathways elicited through G-protein-coupled receptors (GPCRs). We address the dynamics of signaling complexes at the cell surface and the endocytotic mechanisms that govern receptor trafficking and signal termination. We are especially interested in the function of the late endosome, an important hub for the segregation of incoming cargo and also the site of the endosomal escape for Influenza A as well as other enveloped viruses.
Our comprehensive range of molecular, biochemical and cellular methods includes analysis of gene regulation through microarray and quantitative Real-Time PCR technique, analyses of protein functions in vitro and in vivo using biochemical techniques, cell models, flow cytometry and microscopy.
- Heitzig N, Kühnl A, Grill D, Ludewig K, Schloer S, Galla HJ, Grewal T, Gerke V, Rescher U. (2018). Cooperative binding promotes demand-driven recruitment of AnxA8 to cholesterol-containing membranes. Biochim Biophys Acta. 1863:349-358
- Hessner F, Dlugos CP, Chehab T, Schaefer C, Homey B, Gerke V, Weide T, Pavenstädt H, Rescher U. (2016). CC chemokine receptor 10 cell surface presentation in melanocytes is regulated by the novel interaction partner S100A10. Sci Rep. 4:22649.
- Poeter M, Brandherm I, Rossaint J, Rosso G, Shahin V, Skryabin BV, Zarbock A, Gerke V, Rescher U. (2014). Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63. Nat Commun. 5:3738.
- Quiskamp N, Poeter M, Raabe CA, Hohenester UM, König S, Gerke V, Rescher U. (2014). The tumor suppressor annexin A10 is a novel component of nuclear paraspeckles. Cell Mol Life Sci. 71:311-29.
- Musiol A, Gran S, Ehrhardt C, Ludwig S, Grewal T, Gerke V, Rescher U. (2013). Annexin A6-balanced late endosomal cholesterol controls influenza A replication and propagation. MBio. 4:e00608-13.
- Pupjalis D, Goetsch J, Kottas DJ, Gerke V, Rescher U. (2011). Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling. EMBO Mol Med. 3:102-14.