Milos Galic

Research topic

Our lab investigates how mechanical forces at the plasma membrane are translated into classical biochemical signal transduction cascades.  Mechano-chemical signal translation at cellular membranes has been shown to affect shape and migration of individual cells as well as of cellular ensembles.  However, despite its importance, the underlying molecular mechanisms have largely remained unclear.  To examine the interplay between mechanical forces and biochemical signaling, we apply an interdisciplinary approach combining classical cell biology with biophysical techniques, nanofabrication, and computational analysis of microscopic images. Together, these studies will advance our understanding of how mechanical forces contribute to signal propagation under physiological and pathological conditions.

Publications

  • Saha. T., and Galic, M. (2018) Self-organization across scales: from molecules to organisms. Philos Trans R Soc B (in press),DOI 10.1098/rstb.2017.0113.
  • Saha, T., Rathmann, I., Viplav, A., Panzade, S., Begemann, I., Rasch, C., Klingauf, J., Matis, M., and Galic, M. (2016).Automated analysis of filopodial length and spatially resolved protein concentration via adaptive shape tracking. Molecular biology of the cell 27, 3616-3626
  • Begemann, I., Viplav, A., Rasch, C., and Galic, M. (2015). Stochastic Micro-Pattern for Automated Correlative Fluorescence - Scanning Electron Microscopy. Scientific reports 5, 17973.
  • Galic, M., Begemann, I., Viplav, A., and Matis, M. (2014). Force-control at cellular membranes. Bioarchitecture 4, 164-168.
  • Galic, M., Tsai, F.C., Collins, S.R., Matis, M., Bandara, S., and Meyer, T. (2014). Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. eLife 3.
  • Galic, M., Jeong, S., Tsai, F.C., Joubert, L.M., Wu, Y.I., Hahn, K.M., Cui, Y., and Meyer, T. (2012). External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nature cell biology 14, 874-881.
Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!