Markus Missler

Research Topic

Our research addresses the mechanisms of how nerve cells communicate with each other, a fundamental process that occurs at chemical synapses. Specifically, we work on the regulation of synaptic function by cell-adhesion molecules such as neurexins and their ligands, and how these molecules determine neurotransmission and differentiation of synapses. These are important processes that not only form the basis of any sensation or cognition in the normal brain but can also be impaired in neuropsychiatric disorders such as autism or schizophrenia. In current projects, we investigate, for example, the trafficking of neurexins and neurexophilins to synaptic terminals, and how their mobility impacts synaptic function. In addition, we intensely work on the regulation of high voltage-gated calcium channels by neurexins, and how the alpha2delta auxiliary subunits of VGCC are involved in this regulation.

Related Publications

  • Martinelli, D.C., Chew, K.S., Rohlmann, A., Lum, M.Y., Ressl, S., Hattar, S., Brunger, A.T., Missler, M., and Südhof, T.C. (2016) Expression of C1ql3 in discrete neuronal populations controls efferent synapse numbers and diverse behaviors. Neuron 91, 1-18.
  • Neupert, C., Schneider, R., Klatt, O., Reissner, C., Repetto, D., Biermann, B., Niesmann, K., Missler, M., and Heine, M. (2015) Regulated dynamic trafficking of neurexins inside and outside of synaptic terminals. Journal of Neuroscience 35, 13629-47.
  • Born, G., Breuer, D., Wang, S., Rohlmann, A., Coulon, P., Vakili, P., Reissner, C., Kiefer, F., Heine, M., Pape, H.C., and Missler, M. (2014). Modulation of synaptic function through the alpha-neurexin-specific ligand neurexophilin-1. Proc Natl Acad Sci U S A 111, E1274-1283.
  • Reissner, C., Runkel, F., and Missler, M. (2013). Neurexins. Genome Biol 14, 213
  • Niesmann, K., Breuer, D., Brockhaus, J., Born, G., Wolff, I., Reissner, C., Kilimann, M.W., Rohlmann, A., and Missler, M. (2011). Dendritic spine formation and synaptic function require neurobeachin. Nature Commun 2, e557.
  • Reissner, C., Klose, M., Fairless, R., and Missler, M. (2008). Mutational analysis of the neurexin/neuroligin complex reveals essential and regulatory components. Proc Natl Acad Sci U S A 105, 15124-15129.
  • Zhang, W., Rohlmann, A., Sargsyan, V., Aramuni, G., Hammer, R.E., Südhof, T.C., and Missler, M. (2005). Extracellular domains of alpha-neurexins participate in regulating synaptic transmission by selectively affecting N- and P/Q-type Ca2+ channels. Journal of Neuroscience 25, 4330-4342.
  • Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R.E., Gottmann, K., and Südhof, T.C. (2003). Alpha-neurexins couple Ca2+ channels to synaptic vesicle exocytosis. Nature 423, 939-948.
     

 

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!