Erez Raz

Research topic

We are investigating the mechanisms controlling germ cell fate and migration using zebrafish as an in vivo model. We study the control over the acquisition and maintenance of the germ cell fate and determine the precise roles specific molecules play in this critical developmental event. In addition, we are studying the process of germ cell motility and directed migration. A specific aspect of the second research direction relates to the formation of the gonad in the vertebrate organism. This topic is investigated in the context of the CRC where we focus on the identification of tissues and structures important for the positioning of the migratory germ cells. We  conduct functional analysis of specific molecules expressed in cells located within the region where the gonad develops. In this way we define the molecular mechanisms controlling cell-cell interactions that regulate the 3-dimensional organisation of the organ.

Recent Publications

-Goudarzi, M., Tarbashevich, K., Mildner, K., Begemann, I., Garcia, J., Paksa, A., Reichman-Fried, M., Mahabaleshwar, H., Blaser, H., Hartwig, J., Zeuschner, D., Galic, M., Bagnat, M., Betz, T., Raz E. (2017) Bleb expansion in migrating cells depends on supply of membrane from cell surface invaginations. Developmental Cell 43 (5):577–587.
-Goudarzi,M., Mildner, K., Babatz, F., Riedel, D., Klämbt, C., Zeuschner, D., Raz, E. (2015)  Correlative Light and Electron Microscopy of Rare Cell Populations in Zebrafish Embryos Using Laser Marks. Zebrafish. 12(6): 470-473. 
-Gross-Thebing, T., Yigit, S., Pfeiffer, Reichman-Fried, M., Bandemer, J., Ruckert, C, Rathmer, C., Goudarzi, M., Stehling, M., Tarbashevich, K., Seggewiss, J., Raz, E. (2017) The vertebrate protein Dead end maintains primordial germ cell fate by inhibiting somatic differentiation. Developmental cell 43 (6):704-715 
-Gross-Thebing, T.*, Paksa, A.*, Raz, E. (2014) Simultaneous high-resolution detection of multiple transcripts combined with localization of proteins in whole-mount embryos. BMC Biology, 12(1):55. *Equal contribution
- Hartwig, J., Tarbashevich, K., Seggewiß, J., Stehling, M., Bandemer, J., Grimaldi, C., Paksa, A., Gross-Thebing, T., Meyen, D., Raz, E. (2014) Temporal control over the initiation of cell motility by a regulator of G-protein signaling. Proceedings of the National Academy of Science USA, 111(31):11389-94.
-Hörner F., Meissner R., Polali S., Pfeiffer J., Betz T., Denz C., Raz E. (2017) Holographic optical tweezers-based in vivo manipulations in zebrafish embryos.Journal of  Biophotonics. DOI 10.1002/jbio.201600226.
-Malhotra, D, Shin, J, Solnica-Krezel, J., Raz, E. (2018) Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLife 2018;7:e37888.
-Meyen, D., Tarbashevich, K., Banisch, T.U., Wittwer, C., Reichman-Fried, M., Maugis, B., Grimaldi, C., Messerschmidt, E., Raz, E.(2015) Dynamic filopodia are required for chemokine-dependent intracellular polarization during guided cell migration in vivo. eLife 2015;4:e05279.
-Paksa, A. Raz, E. (2015)  Zebrafish germ cells: motility and guided migration.  Current Opinion in Cell Biology 36:80–85.
-Paksa, A., Bandemer, J., Hoeckendorf, B., Razin N., Tarbashevich, K., Minina, S., Meyen, D., Biundo, A., Leidel, S.A., Peyrieras, N., Gov, N.S., Keller, P.J., Raz, E. (2016) Repulsive cues combined with physical barriers and cell–cell adhesion determine progenitor cell positioning during organogenesis. Nature Communications 7:11288. doi:10.1038/ncomms11288.
-Pfeiffer, J.*, Tarbashevich, K.*, Bandemer, J., Palm, T., Raz, E. (2018) Rapid progression through the cell cycle ensures efficient migration of primordial germ cells - the role of Hsp90. Developmental Biology. pii: S0012-1606(17)30563-8. doi: 10.1016/j.ydbio.2018.02.014. *Equal contribution.
-Tarbashevich, K., Reichman-Fried, M., Grimaldi, C, Raz, E. (2015) Chemokine-Dependent pH Elevation at the Cell Front Sustains Polarity in Directionally Migrating Zebrafish Germ Cells. Current Biology 25(8):1096-1103.


Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!