Neele Wolterhoff

Par-1 regulation in dendrite pruning in Drosophila

The developmentally regulated degeneration of axons and dendrites without loss of the parent neuron, also known as pruning, is an important specificity mechanism during neuronal circuit formation in vertebrates, as well as invertebrates. We use c4da neurons of Drosophila melanogaster as a model system to study this process. During pruning, local microtubule disassembly leads to extensive thinning of dendrites in their proximal regions and enables severing at these sites later on. I am investigating how the kinase Par-1, a key regulator of microtubule disassembly, is regulated during this process and how the phosphatase PP2A contributes to c4da dendrite pruning.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!