Lukas Windgasse

Investigating mechanical loading at intercellular junctions

Desmosomes are intercellular adhesion complexes that form important cellular interfaces between neighboring epithelial cells. Although the essence of desmosomes for the mechanical integrity of mammalian tissue has been recognized, their function on molecular level remains unclear.

In my project, I will investigate the molecular details of desmoplakin-mediated force transduction in epithelial cells. In particular, how the expression of distinct keratin networks affects desmoplakin mechanics. Additionally, I aim at the simultaneous analysis of desmosome and adherens junction mechanics using a FRET multiplexing approach to evaluate how externally applied forces affect the loading of
desmosomes as compared to adherens junctions.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!