Jurij Froese

The role of direct heparan sulfate interactions and Ca2+ complexation for cell-surface restricted Hedgehog transport in vitro

Hedgehog (Hh) proteins act as morphogens that transmit positional information to embryonic cells to steer their differentiation. All vertebrate and invertebrate Hh morphogen family members firmly tether to the outer plasma membrane leaflet of their producing cells where they form multimers. How these multimers are transported to the receiving cells is still unknown.

What is known is that cell surface Heparan sulfate proteoglycans (HSPG) are essential for Hh morphogen function. It is also known that two Ca2+ ions of unknown function are complexed in all Hh family members close to the HS binding site.

I am characterizing the nature of the Hh/HSPG interaction and its dependency on Ca2+ complexation by biochemical means.

 

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!