Julia Fiedler

Cell polarity and cell cycle regulation

Loss of the apical-basal cell polarity and cell-cell adhesion is a crucial step in the pathogenesis of epithelial tumors. Proteins of the Crumbs complex do not only influence apical-basal polarity and formation of tight junctions but also regulate cell size, proliferation, migration and thus may promote the growth of the primary tumor and metastasis.

Using MDCK cells and different human tumor cell models as well as a variety of molecular biological/biochemical and imaging techniques I aim to reveal the underlying functional mechanisms and relevant interaction partners of the Crumbs complex.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!