Jone Isasti Sanchez

Dynamic remodeling of cell vertices in the Drosophila follicle epithelium

Vitellogenesis, the process of yolk formation in the oocyte, is a key process in the development of the oocyte and the posterior formation of a mature egg in all oviparous animals. The first step of yolk formation is the deposition of Yolk Protein (YP) (aka Vitellogenin) into the oocyte by clathrin-mediated endocytosis. In Drosophila the major part of the YP is synthetized in the fat body (the analog of the liver in insects) and has to be afterwards transported through the hemolymph to the egg chamber and cross the FE to reach the oocyte surface. For this purpose, follicular cells (FCs) shrink, creating transient intercellular channels at three-cell vertices that allow the paracellular transport of the YP. This condition, termed patency, even though described in the 70s, has not been further investigated and the cellular events underlying remain unknown.

 

In my project, I aim to shed light on the mechanisms triggering patency, focusing on the specific removal of adhesion proteins from three cell vertices, by the use of genetic and microscopy tools.

 

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!