Fabian Gude

The role of direct heparan sulfate interactions and Ca2+ complexation in Hedgehog gradient formation in vivo

Hedgehog (Hh) proteins are morphogens, which play a central role in cell fate decision making, growth and patterning of different tissues, by forming a highly regulated gradient. The precise mechanisms by which Hh transport and signaling are established and regulated remain elusive. A further essential factor for unimpaired Hh functionality are cell surface heparan sulfate proteoglycans (HSPG), which facilitate multimeric cluster formation and play crucial roles in Hh gradient formation. In this work the nature of the Hh/HSPG interactions, as well as an involvement of, in Hh complexed Ca2+ will be characterized, with and overall focus on the in vivo model Drosophila melanogaster.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!