Bente Winkler

Immune response to inflammation in the CNS of Drosophila

The central nervous system (CNS) can be considered as an immune-privileged organ that is separated from the remaining body by the blood-brain barrier (BBB). The immune response of the nervous system must be tightly controlled to prevent further neurodegeneration. However, the role of infiltrated blood-derived macrophages during the immune response to neurodegeneration has not been fully understood.

We developed an injury model in Drosophila melanogaster where glial immunity induction triggers the infiltration of external macrophages into the pupal CNS. I use this model to investigate the underlying mechanisms of macrophage migration over the BBB as well as a possible detrimental or supportive role of macrophages during CNS immune challenges.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!