Project A08

Molecular Parameters for the Dynamic Assembly of Hedgehog Signaling Platforms

All Hedgehog (Hh) morphogens are dually lipidated proteins that firmly tether to the extracellular plasma membrane leaflet of their producing cells. There, Hhs multimerize into light-microscopically visible signaling platforms. These platforms serve as storage for Hh multimers at the cell surface, but also recruit and activate factors required for their regulated release. However, the hierarchical assembly and molecular structure of Hh platforms as determinants of subsequent modes of Hh spreading and morphogen function are only poorly understood. We will thus characterize the molecular mechanisms that govern dynamic Hh platform assembly as well as Hh platform structure and molecular composition.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!