Stefan Luschnig

Research Topics

Our research addresses cellular, molecular, developmental and functional aspects of epithelial biology. In particular, we investigate how the shapes and dimensions of epithelial tubes are controlled. We use primarily the Drosophila tracheal (respiratory) system, a network of gas-filled tubes, as an accessible model. We apply molecular, genetic, cell biological and quantitative imaging approaches to analyze cellular behavior during tube morphogenesis. Answering basic questions about lumen formation and conversion of cellular topology in the Drosophila model provides a conceptual framework to help elucidate similar processes, such as vascular anastomosis, in more complex vertebrate systems.

Related Publications

  • Byri, S., Misra, T., Syed, Z.A., Batz, T., Shah, J., Boril, L., Glashauser, J., Aegerter-Wilmsen, T., Matzat, T., Moussian, B., et al. (2015). The Triple-Repeat Protein Anakonda Controls Epithelial Tricellular Junction Formation in Drosophila. Developmental Cell 33, 535-548.
  • Caviglia, S., Brankatschk, M., Fischer, E.J., Eaton, S., and Luschnig, S. (2016). Staccato/Unc-13-4 controls secretory lysosome-mediated lumen fusion during epithelial tube anastomosis. Nat Cell Biol 18, 727-739.
  • Caviglia, S., and Luschnig, S. (2014). Tube fusion: Making connections in branched tubular networks. Seminars in cell & developmental biology 31, 82-90.
  • Förster, D., and Luschnig, S. (2012). Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. Nature cell biology 14, 526-534.
  • Misra, T., Baccino-Calace, M., Meyenhofer, F., Rodriguez-Crespo, D., Akarsu, H., Armenta-Calderon, R., Gorr, T.A., Frei, C., Cantera, R., Egger, B., et al. (2017). A genetically encoded biosensor for visualising hypoxia responses in vivo. Biol Open 6, 296-304.
  • Sauerwald, J., Soneson, C., Robinson, M.D., and Luschnig, S. (2017). Faithful mRNA splicing depends on the Prp19 complex subunit faint sausage and is required for tracheal branching morphogenesis in Drosophila. Development (Cambridge, England) 144, 657-663.