Kristina Ehring

Molecular parameters for the dynamic assembly of Hedgehog signaling platforms

Hedgehog (Hh) morphogens are important signaling molecules during embryonic development and tissue homeostasis. They are dually lipidated and tether to the plasma membrane after their secretion. On the cell surface Hhs form multimers, to which factors required for their release will be recruited. Another important factor known to be involved in Hh release is called Dispatched (Disp), but so far, the exact function of Disp is unknown.

In our group we use cell culture and the model organism Drosophila melanogaster to study the molecular mechanism that governs Hh platform assembly, structure and Hh release and the role of Disp in this process.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!