Pilot Project 2 (2019)

Exploring the interaction between tricellular occluding junctions (TCJs) and adherens junctions (AJs) and its possible role in epithelial polarization

In this project, we aim to decipher the complex interactions between Adherens Junctions (AJs) and Tight Junctions (TJCs) and analyze the role of TJCs in the acquisition and / or maintenance of epithelial apico-basal polarity in early mouse embryonic development and Drosophila oogenesis. We hypothesize that TCJs act as a “break” to restrict AJ localization before the apical domain. Therefore, we suggest that the interplay between AJs and TCJs determines the spatial segregation of the apical and lateral domains in polarized epithelia. We will follow three specific aims:

  • Aim 1: Analyzing the role of TCJs in the epithelialization of the mouse epiblast cells
  • Aim 2: Assessing the role of E-cadherin in Drosophila FCE and mouse ESCs on the formation of TCJs and the apico-basal polarity
  • Aim 3: Assessing the degree of conservation of TCJ formation in invertebrates and vertebrates
Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!