Project B06

Cell-Cell Interactions Controlling Organ Shape

The precise positioning of organ progenitor cells constitutes an essential, yet poorly understood step in organogenesis. Using zebrafish primordial germ cells (PGCs) as an in vivo model for this process, we propose to study the cellular interactions that contribute to the organization of this cell population with respect to other structures in the embryo, mechanisms that shape the early developing gonad. We have previously defined roles for structures that are important for maintenance of the separation between the two bilateral clusters of motile cells, as well as for limiting PGC migration in the dorsal direction and keep analyzing this early stage in gonad formation. Nevertheless, the later establishment of more stable interactions of the PGCs with tissues located in this region was not studied. The proposed project will first focus on the identification of additional cell populations the PGCs interact with. In addition we will identify molecules expressed in the environment and in the PGCs, molecules that are involved in the interactions leading to stable positioning of the cells within the developing organ. This will be followed by functional analysis aimed at determining the importance of the identified structures and molecules in controlling the 3-dimensional arrangement of the tissue.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!