Project A09

Regulation of Vesicle Formation in Clathrin-Independent Endocytosis

Tetraspanin-enriched microdomains (TEM) act as platforms in the plasma membrane regulating various biological processes. Depending on the composition of TEM, tetraspanins modulate, stabilize, or prevent the activities of associated molecules. In this project, we will analyze the role of the dynamic composition of TEM for induction and execution of a novel endocytic mechanism used by human papillomaviruses (HPV) for infection. In particular, we are interested in the recruitment of cellular factors regulating membrane bending and scission. Likewise, we aim to address the impact of endocytosis on the virus-induced, TEM-mediated signaling outcome.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!