Pilot Projects

All graduate students of the CRC 1348 have the chance to apply for funding for innovative and risky projects that they develop in collaboration with other students of the CRC. This will foster interaction among students, exchange of ideas, and will guide the students into creativity and independence.

A technique to visualize specific cell-surface heparan sulfate proteoglycans in vivo in Drosophila melanogaster

Heparan sulfate (HS) proteoglycans are dynamically expressed at the surface of virtually all cell types and act as essential regulators of growth and

Exploring the interaction between tricellular occluding junctions (TCJs) and adherens junctions (AJs) and its possible role in epithelial polarization

In this project, we aim to decipher the complex interactions between Adherens Junctions (AJs) and Tight Junctions (TJCs) and analyze the role of TJCs

Mutations in VE-PTP: Identification of a Novel Cause of Venous Malformations in 3D-Matrices

Mutations in the vascular endothelial protein tyrosine phosphatase (VE-PTP), one of the most important interaction partners of angiopoietin receptor T

Tools to investigate spatiotemporal kinase signaling in epithelial and neuronal polarity

The preliminary data our two groups (Krahn, Rumpf) allow to suggest that Par-1 activity is regulated spatially and temporally in a dynamic way. The a

Biosensors to study membrane curvature stabilization during HPV16 endocytosis

Viruses are obligatory intracellular parasites that hijack cellular mechanisms for host cell entry and replication. Therefore, they are valuable tools

Identifying regulators of late endosomal cholesterol homeostasis and post-endosomal trafficking routes using proximity proteomics

Late endosomes and lysosomes control intracellular trafficking routes by monitoring the cellular homeostasis of cholesterol. Cholesterol is taken up b

Optogenetic tool for manipulating cell-cell adhesion in cultured cells and in vivo

In multicellular organisms, cells need to form stable but reversible connections with each other to allow compartmentalization of the organisms. Cell

Shedding light on inter-organellar communication: An optogenetic approach to investigate organelle contact sites

The group of Maria Bohnert investigates the biology of organelle contact sites, specialized structures where the membranes of different cellular organ

Light-regulated protein degradation of fly Nephrin to monitor slit diaphragm dynamics in Drosophila nephrocytes

Many renal diseases show a severe phenotype of filtration defects in the glomeruli of the kidney. Since podocytes and the slit diaphragms they compose