Project A07

Regulation of Growth Factor Signaling by the Nanoscale Presentation of the Extracellular Matrix

The coordination of adhesion receptor signals with those from growth factor receptors provides a key regulatory mechanism that controls many basic cell functions. While the importance of the extracellular matrix (ECM) in regulating integrin signaling has been shown, very little is known about how the physical presentation of other matrix-bound biomolecules, in particular growth factors, affects their signaling potential and ability to crosstalk with integrins through signaling events at cellular membranes. Here, we will use a synthetic hydrogel material to investigate how vascular endothelial growth factor (VEGF) signaling is controlled by the presentation of VEGF and adhesive ligands regulating their clustering at the cell membrane.

Rafael being pulled to the Badestrasse after the graduation ceremony

Rafael Krämer - first graduated PhD Student from the CRC1348 IRTG

We are happy to announce that in December 2019 Rafael Krämer from the Rumpf lab was graduated as first PhD student from the CRC1348 IRTG. Congratulations Dr. Krämer and well done!

CRC1348 Retreat 2019 Oberwerries

CRC 1348 Retreat 2019 Oberwerries

The CRC has staged a successful and productive annual retreat at the Landesturnschule Oberwerries with lots of mental and some physical exercise. We are due to return fully equipped with sweat pants, trainers and shower gel in 2020!